Bioinformatics Research Collective

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Summary: Optimal Trade-Off Control in Machine Learning-Based Library Design for AAV-Mediated Gene Therapies
Introduction Adeno-associated virus (AAV)-mediated gene therapy holds significant promise for treating monogenic disorders of the central nervous system…
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Emily M. Liau
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Primer: Non-Linear Dimensionality Reduction Techniques for Single-Cell Transcriptomics
Overview Due to low coverage in high-throughput sequencing experiments, dimensionality reduction techniques are commonly applied towards single-cell…
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Emily M. Liau
Primer: Genome Assembly
Overview Genome assembly refers to the process of accurately constructing a contiguous representation of nucleotides based on a collection of smaller…
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Emily M. Liau
Primer: Genome Sequencing
Overview Genome sequencing refers to the process of determining the exact order of the entirety of nucleotides in an organism’s genome at a single time.
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Emily M. Liau
Summary: High-Throughput 5' UTR Engineering for Enhanced Protein Production in Non-Viral Gene Therapies
Introduction Gene therapy encompasses a set of therapeutic modalities intended to treat genetic and acquired diseases, by directly administering nucleic…
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Emily M. Liau
Bioinformatics Research Collective
Bioinformatics Research Collective
An academic newsletter about bioinformatics, featuring topics at the intersection of data science, genomics, statistics, and bioethics.
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